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Cabezón E, Ripoll-Rozada J, Peña A, de la Cruz F Arechaga I. Towards an integrated models of bacterial conjugation. FEMS Microbiol. Rev. 2015, 39, 81-95. DOI:10.1111/1574-6976.12085


Peña A, Arechaga I. Molecular motors in bacterial secretion. J. Mol. Microbiol.Biotech. 2013, 23(4-5), 357-69. DOI:10.1159/000351360

Ripoll-Rozada J, Zunzunegui, S., de la Cruz F, Arechaga I, Cabezón E,. Functional interactions of VirB11 traffic ATPases with VirB4 and VirD4 molecular motors in type IV secretion systems. J. Bacteriol. 2013, 195(18), 4195-201. DOI:10.1128/JB.00437-13

Arechaga I. Membrane invaginations in bacteria and mitochondria: common features and evolutionary scenarios. J. Mol. Microbiol.Biotech. 2013, 23(1-2), 13-23. DOI:1159/000346515


Peña A, Martíin-Benito J, Valpuesta JM, Carrascosa JL, de la Cruz F, Cabezón E, Arechaga I. The hexameric structure of a conjugative VirB4 protein ATPase provides new insights for a functional and phylogenetic relationship with DNA translocases. J. Biol. Chem. 2012, 287(47), 39925-32. DOI:10.1074/jbc.M112.413849

Ripoll-Rozada J, Peña A, Rivas S, Moro F, de la Cruz F, Cabezón E,Arechaga I. Regulation of the type IV secretion ATPase TrwD by magnesium: implications for the catalytic mechanism of the secretion ATPase superfamily. J. Biol. Chem. 2012, 287(21), 17408-14. DOI:10.1074/jbc.M112.357905

Cabezón E, Lanza VF, Arechaga I. Membrane-associated nanomotors form macromolecular transport Curr. Opin. Biotechnol. 2012, 23(4), 537-44. DOI:10.1016/j.copbio.2011.11.031


Kumar R, Ferez M, Swamy M, Arechaga I, Rejas MT, Valpuesta JM, Schamel WW, Alarcón B, van Santen HM. Increased sensitivity of antigen-experienced T cells through the enrichment of oligomeric T cell receptor complexes Immunity 2011, 35(3), 375-87. DOI:10.1016/j.immuni.2011.08.010

Peña A, Ripoll-Rozada J, Zunzunegui S, Cabezón E, de la Cruz F, Arechaga I. Autoinhibitory regulation of TrwK, an essential VirB4 ATPase in type IV secretion systems J. Biol. Chem. 2011, 286(19), 17376-82. DOI:10.1074/jbc.M110.208942


Canone J, Marino D, Noel LD, Arechaga I, Pichereaux C, Rossignol M, Roby D, Rivas S. Detection and functional characterization of a 215 amino acid N-terminal extension in the Xanthomonas type III effector XopD PLOS One 2010, 22(5), e15773. DOI:10.1371/journal.pone.0015773

Arechaga I, Swamy M, Abia D, Schamel WW, Alarcón B, Valpuesta JM. Structural characterization of the TCR complex by electron microscopy Int. Immunol. 2010, 22(11), 897-903. DOI:10.1093/intimm/dxq443

Matilla I, Alfonso C, Rivas G, Bolt EL, de la Cruz F, Cabezón E. The conjugative DNA translocase TrwB is a structure specific DNA-binding protein. J. Biol. Chem. 2010, 285(23, 17537-44. DOI:10.1074/jbc.M109.084137

Arechaga I, Martínez-Costa OH, Ferreras C, Carrascosa JL, Aragón JJ. Electron microscopy analysis of mammalian phosphofructokinase reveals an unusual 3-dimensional structure with significant implications for enzyme function FASEB J. 2010, 24(12), 4960-8. DOI:10.0024-4960


Mihajlovic S, Lang S, Sut MW, Strohmaier H, Gruber CJ, Koraimann G, Cabezón E, Moncalián G, de la Cruz F,Zechner EL . Plasmid r1 conjugative DNA processing is regulated at the coupling protein interface. J. Bacteriol. 2009, 19(22), 6877-87. DOI:10.1128/JB.00918-09


Arechaga I, Peña A, Zunzunegui S, Del Carmen Fernández-Alonso M, Rivas G, de la Cruz F. ATPase activity and oligomeric state of TrwK, the VirB4 homologue of plasmid R388 Type IV secretion system. J. Bacteriol. 2008, 190(15), 5472-9. DOI:10.1128/JB.00321-08


Tato I, Matilla I, Arechaga I, Zunzunegui S, de la Cruz F, Cabezón E. The ATPase activity of the DNA transporter TrwB is modulated by protein TrwA: Implications for a common assembly mechanism of DNA translocating motors. J. Biol Chem. 2007, 282(35), 25569-76. DOI:10.1074/jbc.M703464200

Arechaga I, Fotiadis D. Reconstitution of mitochondrial ATP synthase into lipid bilayers for structural analysis. J. Struct. Biol. 160(3, 287-94. DOI:10.1016/j.jsb.2007.09.07


Cabezón E, de la Cruz F "TrwB: An F1-ATPase-like molecular motor involved in DNA transport during bacterial conjugation". Res. Microbiol. 2006, 157:299–305. DOI:10.1016/j.resmic.2005.12.002


Schamel W W A, Arechaga I, Risueño RM, van Santen HM, Cabezas P, Risco C, Valpuesta JM, Alarcón B. "Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response". J Exp Med. 2005, 202:493–503. DOI:10.1084/jem.20042155

Tato I, Zunzunegui S, de la Cruz F, Cabezón E. "TrwB, the coupling protein involved in DNA transport during bacterial conjugation, is a DNA-dependent ATPase". Proc Natl Acad Sci USA 2005, 102:8156-61. DOI:10.1073/pnas.0503402102


Cabezón E, Montgomery MG, Leslie AG, Walker JE. (2003) "The structure of bovine F1-ATPase in complex with its regulatory protein IF1." Nat Struct Biol. 10(9):744-50. DOI:10.1038/nsb966

Arechaga, I., Miroux, B., Runswick, M. J. & Walker, J. E. (2003). "Over-expression of Escherichia coli F1F(o)-ATPase subunit a is inhibited by instability of the uncB gene transcript". FEBS Lett 547, 97-100. DOI:10.1016/S0014-5793(03)00677-X

Jekabsons, M. B., Echtay, K. S., Arechaga, I. & Brand, M. D. (2003). "Molecular properties of purified human uncoupling protein 2 refolded from bacterial inclusion bodies". J Bioenerg Biomembr 35, 409-18. DOI:10.1023/A:1027335713635

Murata, T*., Arechaga, I*., Fearnley, I. M., Kakinuma, Y., Yamato, I. & Walker, J. E. (2003). (*equal contributors) "The membrane domain of the Na+-motive V-ATPase from Enterococcus hirae contains a heptameric rotor". J Biol Chem 278, 21162-7. DOI:10.1074/jbc.M301620200

Martinez LO, Jacquet S, Esteve JP, Rolland C, Cabezon E, Champagne E, Pineau T, Georgeaud V, Walker JE, Terce F, Collet X, Perret B, Barbaras R. (2003) "Ectopic beta-chain of ATP synthase is an apolipoprotein A-I receptor in hepatic HDL endocytosis." Nature 421:75-9. DOI:10.1038/nature01250


Cabezón, E., Butler, P.J., Runswick, M.J., Carbajo, R.J., and Walker, J.E. (2002) "Homologous and heterologous inhibitory effects of ATPase inhibitor proteins on F-ATPases." J Biol Chem . 277: 41334-41341. DOI:10.1074/jbc.M207169200

Arechaga, I., Butler, P. J. & Walker, J. E. (2002). "Self-assembly of ATP synthase subunit c rings". FEBS Lett 515, 189-93. DOI:10.1016/S0014-5793(02)02447-X

Ledesma, A., de Lacoba, M. G., Arechaga, I. & Rial, E. (2002). "Modeling the transmembrane arrangement of the uncoupling protein UCP1 and topological considerations of the nucleotide-binding site". J Bioenerg Biomembr 34, 473-86. [pdf]


Arechaga, I., Ledesma, A. & Rial, E. (2001). "The mitochondrial uncoupling protein UCP1: a gated pore". IUBMB Life 52, 165-73. DOI:10.1080/15216540152845966

Arechaga, I. & Jones, P. C. (2001). "The rotor in the membrane of the ATP synthase and relatives". FEBS Lett 494, 1-5. DOI:10.1016/S0014-5793(01)02300-6

Arechaga, I. & Jones, P. C. (2001). "Quick guide: ATP synthase". Curr Biol 11, R117. DOI:10.1016/S0960-9822(01)00055-0

Cabezón, E., Runswick, M.J., Leslie, A.G., and Walker, J.E. (2001) "The structure of bovine IF(1), the regulatory subunit of mitochondrial F-ATPase". EMBO J. 20: 6990-6996. DOI:10.1093/emboj/20.24.6990


Cabezón, E., Butler, P.J., Runswick, M.J., and Walker, J.E. (2000) "Modulation of the oligomerization state of the bovine F1-ATPase inhibitor protein, IF1, by pH." J Biol Chem. 275: 25460-25464. DOI:10.1074/jbc.M003859200

Cabezón, E., Arechaga, I., Jonathan, P., Butler, G., and Walker, J.E. (2000). "Dimerization of bovine F1-ATPase by binding the inhibitor protein, IF1" J Biol Chem. 275: 28353-28355. DOI:10.1074/jbc.C000427200

Arechaga, I., Miroux, B., Karrasch, S., Huijbregts, R., de Kruijff, B., Runswick, M. J. & Walker, J. E. (2000). "Characterisation of new intracellular membranes in Escherichia coli accompanying large scale over-production of the b subunit of F(1)F(o) ATP synthase". FEBS Lett 482, 215-9. DOI:10.1016/S0014-5793(00)02054-8

Stock, D., Gibbons, C., Arechaga, I., Leslie, A. G. & Walker, J. E. (2000). "The rotary mechanism of ATP synthase". Curr Opin Struct Biol 10, 672-9. DOI:10.1016/S0959-440X(00)00147-0


Molecular Motors Group - Elena Cabezón and Ignacio Arechaga
. Instituto de Biomedicina y Biotecnología de Cantabria.
Albert Esintein 21, PCTCAN,39011 Santander (Spain). Tel. +34 942 202033