Nanoporous Graphene Integrated onto Bimodal Waveguide Biosensors for Detection of C-Reactive Protein
Recent advances in photonic sensor devices face a significant challenge in the surface biofunctionalization step—specifically, the reliable immobilization of biorecognition elements onto sensor surfaces. In a breakthrough development, researchers have integrated bottom-up synthesized nanoporous graphene onto bimodal waveguide interferometric biosensors, creating an atomically precise biofunctionalization scaffold.
This novel combination takes advantage of the high sensitivity of bimodal waveguide interferometers and the large functional surface area of nanoporous graphene, resulting in highly sensitive, selective, and robust biosensors. These sensors enable the direct immunoassay detection of C-reactive protein (CRP), a key inflammatory biomarker used in diagnosing infections and sepsis.
With a limit of detection as low as 3 ng/mL—well below the clinical cutoff levels for CRP detection—this innovative approach promises to significantly impact diagnostic technologies, environmental monitoring, and any field requiring precise biomolecular detection.